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Synthesis 2011(24): 3975-3978  
DOI: 10.1055/s-0031-1289582
PSP
© Georg Thieme Verlag Stuttgart ˙ New York

A New and Convenient Method for the Preparation of Functionalized Phosphorothioates

Slawomir Lach*, Dariusz Witt*
Department of Organic Chemistry, Chemical Faculty, Gdansk University of Technology, Narutowicza 11/12, 80-233 Gdansk, Poland
Fax: +48(58)3472694; e-Mail: slach@chem.pg.gda.pl; e-Mail: dwitt@chem.pg.gda.pl;
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Publication History

Received 6 September 2011
Publication Date:
27 October 2011 (online)

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Abstract

A new and efficient method for the synthesis of alkyl and aryl phosphorothioates in high yields via the reaction of (5,5-dimethyl-2-thioxo-1,3,2-dioxaphosphorin-2-yl)disulfanyl derivatives with trimethyl phosphite is described.

Key words

phosphorothioates - trimethyl phosphite - Arbuzov reaction - thiols - l-cysteine

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